Nutritional support of critically ill infants and children has a major
impact on the morbidity and ultimate survival of these patients. Pare
nteral nutrition has undergone many changes since its original use mor
e than 20 years ago. This article summarizes some of the more recent m
odifications in parenteral nutrition. The use of insulin to control hy
perglycemia associated with parenteral nutrition is controversial, alt
hough many advocate its use as a means to optimize caloric intake in t
he very low-birthweight infant for whom this is often a significant pr
oblem. The advantages of using a 20% lipid emulsion, as opposed to a 1
0% emulsion, are emphasized. Supplementation with carnitine and seleni
um is controversial, and studies endorsing and opposing their use are
described.