Mg. Gonzalez et al., EFFECTS OF CASIMIROA-EDULIS (RUTACEA) ON BLOOD-PRESSURE AND CARDIAC FREQUENCY OF ALBINO-RATS, Revista de biologia tropical, 42(1-2), 1994, pp. 115-119
Aqueous extracts of Casimiroa edulis leaves injected intravenously to
20 normal Spague-Dawley rats produced a rapid and transitory increase
in blood pressure. The amplitude of the blood pressure rise was dose d
ependent. The increase was statistically significant (p less than or e
qual to 0.01) at a concentration of 220 mOsm/l, and was associated wit
h a significant heart rate decrease (p less than or equal to 0.01) pro
bably secondary to barorreceptor stimuli. The application of 130 mOsm/
l of the extract did not produce a significant increase in blood press
ure, which was followed by a rapid pressure normalization. The slight
increase in cardiac rate during the pressure lift was probably due to
sympathetic stimuli.