HEPATOMA MERBARONE - A SOUTHWEST-ONCOLOGY-GROUP STUDY

Authors
POPLIN EA TANGEN CM HARVEY WH MACDONALD JS
Citation
Ea. Poplin et al., HEPATOMA MERBARONE - A SOUTHWEST-ONCOLOGY-GROUP STUDY, Investigational new drugs, 12(4), 1994, pp. 337-340
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
Journal title
Investigational new drugs → ACNP
ISSN journal
01676997
Volume
12
Issue
4
Year of publication
1994
Pages
337 - 340
Database
ISI
SICI code
0167-6997(1994)12:4<337:HM-ASS>2.0.ZU;2-6
Abstract
Sixteen eligible patients with hepatocellular carcinoma, previously un treated, received merbarone 1000 mg/m(2)/d for five consecutive days e very 21 days. No complete or partial response to treatment was obtaine d. Seven patients had grade 4 granulocytopenia. One patient died with renal failure. Merbarone in this dose and schedule was ineffective in the treatment of hepatocellular carcinoma.