DECREASED MOLECULAR CHAPERONE PROPERTY OF ALPHA-CRYSTALLINS DUE TO POSTTRANSLATIONAL MODIFICATIONS

Authors
CHERIAN M ABRAHAM EC
Citation
M. Cherian et Ec. Abraham, DECREASED MOLECULAR CHAPERONE PROPERTY OF ALPHA-CRYSTALLINS DUE TO POSTTRANSLATIONAL MODIFICATIONS, Biochemical and biophysical research communications, 208(2), 1995, pp. 675-679
Citations number
27
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
208
Issue
2
Year of publication
1995
Pages
675 - 679
Database
ISI
SICI code
0006-291X(1995)208:2<675:DMCPOA>2.0.ZU;2-V
Abstract
We studied the effect of oxidation, mixed disulfide formation and glyc ation of alpha-crystallins on their molecular chaperone property. The ability of alpha-crystallins to protect heat-induced denaturation and aggregation of beta L-crystallin was significantly diminished by these modifications. alpha-Crystallin from senile human lenses also showed significant loss of chaperone-like property. Age-dependent increase in posttranslationally modified alpha-crystallins is the likely cause fo r this change. (C) 1995 Academic Press. Inc.