PRESENCE OF BOTH A(1) AND A(2A) ADENOSINE RECEPTORS IN HUMAN-CELLS AND THEIR INTERACTION

Authors
AHMED AH JACOBSON KA KIM JH HEPPEL LA
Citation
Ah. Ahmed et al., PRESENCE OF BOTH A(1) AND A(2A) ADENOSINE RECEPTORS IN HUMAN-CELLS AND THEIR INTERACTION, Biochemical and biophysical research communications, 208(2), 1995, pp. 871-878
Citations number
17
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
208
Issue
2
Year of publication
1995
Pages
871 - 878
Database
ISI
SICI code
0006-291X(1995)208:2<871:POBAAA>2.0.ZU;2-1
Abstract
We have obtained pharmacological evidence for the expression of both A (1)- (inhibitory) and A(2a)- (stimulatory) adenosine receptors in cult ured human foreskin fibroblasts and lung fibroblasts. The Al receptors were sufficiently abundant in foreskin fibroblasts so that binding st udies with a radioactively labeled specific ligand confirmed their exi stence. Both receptors were activated during the stimulation of cAMP a ccumulation and DNA synthesis by adenosine. (C) 1995 Academic Press, I nc.