FLUORO-DIDEUTERO-METHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER (D-2-SEVOFLURANE) REACTIONS ON SODA LIME - DEUTERIUM CONTENT OF DEUTERATED SEVOFLURANE AND ITS VOLATILE DEGRADATION PRODUCTS

Authors
RUZICKA JA BAKER MT
Citation
Ja. Ruzicka et Mt. Baker, FLUORO-DIDEUTERO-METHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER (D-2-SEVOFLURANE) REACTIONS ON SODA LIME - DEUTERIUM CONTENT OF DEUTERATED SEVOFLURANE AND ITS VOLATILE DEGRADATION PRODUCTS, Journal of fluorine chemistry, 71(1), 1995, pp. 55-58
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of fluorine chemistry → ACNP
ISSN journal
00221139
Volume
71
Issue
1
Year of publication
1995
Pages
55 - 58
Database
ISI
SICI code
0022-1139(1995)71:1<55:F1E(>2.0.ZU;2-Q
Abstract
The degradation of the experimental anesthetic, fluoro-dideutero-methy l 1,1,1,3,3,3-hexafluoroisopropyl ether (D-2-sevoflurane) on soda lime (Sodasorb((R))) has been compared with sevoflurane and examined in re gard to product deuterium content. Similar products and rates of degra dation were found between sevoflurane and D-2-sevoflurane, and all D-2 -sevoflurane products contained the fluorodideuteromethoxy group. Four products contained a trideuteromethoxy moiety, indicating the additio n of methanol derived from the fluoromethoxy carbon of D-2-sevoflurane .