CD14 RECEPTOR-MEDIATED UPTAKE OF NONOPSONIZED MYCOBACTERIUM-TUBERCULOSIS BY HUMAN MICROGLIA

Authors
PETERSON PK GEKKER G HU SX SHENG WS ANDERSON WR ULEVITCH RJ TOBIAS PS GUSTAFSON KV MOLITOR TW CHAO CC
Citation
Pk. Peterson et al., CD14 RECEPTOR-MEDIATED UPTAKE OF NONOPSONIZED MYCOBACTERIUM-TUBERCULOSIS BY HUMAN MICROGLIA, Infection and immunity, 63(4), 1995, pp. 1598-1602
Citations number
25
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
4
Year of publication
1995
Pages
1598 - 1602
Database
ISI
SICI code
0019-9567(1995)63:4<1598:CRUONM>2.0.ZU;2-9
Abstract
This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microgl ia. Treatment of microglial cell cultures with antibodies to CD14 or w ith soluble CD14 significantly blocked infection by M. tuberculosis H3 7Rv, suggesting that CD14 receptors could facilitate entry of nonopson ized tubercle bacilli into macrophages within the brain.