IDENTIFICATION OF A PSTI POLYMORPHISM IN THE P21(CIP1 WAF1) CYCLIN-DEPENDENT KINASE INHIBITOR GENE/

Authors
LAW JC DEKA A
Citation
Jc. Law et A. Deka, IDENTIFICATION OF A PSTI POLYMORPHISM IN THE P21(CIP1 WAF1) CYCLIN-DEPENDENT KINASE INHIBITOR GENE/, Human genetics, 95(4), 1995, pp. 459-460
Citations number
4
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
95
Issue
4
Year of publication
1995
Pages
459 - 460
Database
ISI
SICI code
0340-6717(1995)95:4<459:IOAPPI>2.0.ZU;2-H
Abstract
A PstI polymorphism in the 3' flanking region of the p21(Cip1/Waf1) cy clin-dependent kinase inhibitor gene is described. DNA sequencing anal ysis identified a C-->T base substitution in the 3' flanking region of the gene. This substitution leads to the destruction of a PstI site a nd results in a biallelic DNA polymorphism. This restriction fragment length polymorphism (RFLP) provides the first known genetic marker for this cell cycle regulatory gene.