C-TO-T AND OR G-TO-A TRANSITIONS ARE RESPONSIBLE FOR LOSS OF A MSPI RESTRICTION SITE AT THE 5'-END OF THE HUMAN APOLIPOPROTEIN AI GENE/

Authors
WANG XL BADENHOP R HUMPHREY KE WILCKEN DEL
Citation
Xl. Wang et al., C-TO-T AND OR G-TO-A TRANSITIONS ARE RESPONSIBLE FOR LOSS OF A MSPI RESTRICTION SITE AT THE 5'-END OF THE HUMAN APOLIPOPROTEIN AI GENE/, Human genetics, 95(4), 1995, pp. 473-474
Citations number
5
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
95
Issue
4
Year of publication
1995
Pages
473 - 474
Database
ISI
SICI code
0340-6717(1995)95:4<473:CAOGTA>2.0.ZU;2-O
Abstract
We detected the loss of a MspI restriction site by a C to T transition at +83 bp and a G to A transition at +84 bp of the 5'-end non-coding region of the human apolipoprotein AI gene. This base change occurred at the ''hot spot'' (CCGG) for methylation, which may be important in the regulation of gene expression. The population frequency for the lo ss of the MspI site is 6.1%.