Wl. Bonkale et al., REDUCED NITRIC-OXIDE RESPONSIVE SOLUBLE GUANYLYL CYCLASE ACTIVITY IN THE SUPERIOR TEMPORAL CORTEX OF PATIENTS WITH ALZHEIMERS-DISEASE, Neuroscience letters, 187(1), 1995, pp. 5-8
Particulate and soluble guanylyl cyclase activities were studied in po
stmortem temporal cortex from a series of Alzheimer's disease patients
and matched control subjects. Particulate guanylyl cyclase activity w
as not significantly different between groups. In contrast, the V-max
values for basal and sodium nitroprusside-stimulated soluble guanylyl
cyclase activities were approximately 50% lower in the Alzheimer's dis
ease cases, compared to controls. This difference between groups was s
tatistically significant for sodium nitroprusside-stimulated, but not
for the basal, enzyme activities. These results provide the first evid
ence for a loss of nitric oxide responsive guanylyl cyclase activity i
n Alzheimer's disease brain.