EXTRAMAMMARY PAGETS-DISEASE OF THE VULVA

Citation
Da. Fishman et al., EXTRAMAMMARY PAGETS-DISEASE OF THE VULVA, Gynecologic oncology, 56(2), 1995, pp. 266-270
Citations number
24
Categorie Soggetti
Oncology,"Obsetric & Gynecology
Journal title
ISSN journal
00908258
Volume
56
Issue
2
Year of publication
1995
Pages
266 - 270
Database
ISI
SICI code
0090-8258(1995)56:2<266:EPOTV>2.0.ZU;2-Y
Abstract
Fourteen patients with extramammary Paget's disease of the vulva treat ed at Yale-New Haven Medical Center from 1982 through 1993 were review ed to evaluate the accuracy of methods used to delineate surgical marg ins and to determine if radical operations or surgical margin status w as associated with likelihood of recurrence. These 14 patients underwe nt at total of 25 operations for extramammary Paget's disease. In 8 op erations, a total of 44 separate frozen-section biopsies were performe d to determine extent of disease with a mean of 5.5 biopsies per patie nt. Visual judgment alone was used to determine margin status in 17 op erations. The ability to delineate free surgical margins on permanent sections was not different, whether judged visually or by frozen-secti on analysis. Frozen-section analysis was misleading in 3/8 (37.5%) cas es, while visual judgment was in error in 6/17 (35%) cases. Moreover, permanent margin status was not found to be predictive of disease recu rrence. Two of 5 (40%) patients with positive margins recurred after i nitial surgery compared with 3 of 9 (33%) patients with negative margi ns. Of the 14 primary operations, there were 8 wide local excisions, 3 simple vulvectomies, and 3 modified radical vulvectomies. The radical ity of the operation as initial treatment did not statistically correl ate with disease recurrence. (C) 1995 Academic Press, Inc.