J. Gardovskis et al., PROGNOSTIC FACTORS IN CURATIVE RESECTIONS FOR STOMACH CARCINOMA - A UNIVARIATE AND MULTIVARIATE-ANALYSIS, Langenbecks Archiv fur Chirurgie, 380(2), 1995, pp. 75-81
The TNM system, including tumor infiltration (T category), lymph node
infiltration (N category) and metastasis (M category), is a well-estab
lished system of prognostic factors. To evaluate the prognostic import
ance of patient characteristics and tumor parameters 5 clinical and 13
pathological factors were analyzed. Data on 200 consecutive patients
with histologically verified stomach cancer were prospectively recorde
d using a standardized form. In the subgroup with curative resection (
R0, n = 108) a uni- and multivariate analysis was performed with respe
ct to 5-year survival. In the univariate analysis statistical signific
ance was demonstrated for the following factors: tumor size, tumor loc
alization, T category, N category, number of infiltrated lymph nodes i
nfiltrated, lymph node compartments, tumor stage, lymph node ratio: in
filtrated/inspected. Multivariate analysis, taking into consideration
the interaction between prognostic factors, revealed only two factors
as statistically significant: number of infiltrated lymph nodes and tu
mor size. Our results and those in the literature indicate that the in
filtration of lymph nodes is the most relevant prognostic factor. In a
ddition to the TNM system the number of infiltrated lymph nodes seems
to be of prognostic importance.