The purposes of this study were to determine if there were significant
differences in the mood states of oncology outpatients who had cancer
-related pain and those who were painfree, and to evaluate the relatio
nships between pain intensity and duration and mood states in those pa
tients with pain. Two hundred (54.2%) patients experienced cancer-rela
ted pain during the previous month and 169 (45.8%) patients were pain
free. Those patients who experienced cancer-related pain scored signif
icantly higher on all of the subscale scores of the Profile of Mood St
ates, except vigor, and had a significantly higher total mood disturba
nce (TMD) score than did pain-free patients. In addition, the subscale
scores of tension, depression, anger, fatigue confusion, and TMD scor
es were moderately correlated with increases in pain intensity. Also,
depression, fatigue, confusion, and TMD scores were moderately correla
ted with increasing duration of pain. These data suggest that there is
a relationship between pain and mood in oncology outpatients and that
health-care professionals need to assess for mood disturbances in thi
s population and develop appropriate treatment strategies.