Mym. Chen et al., COMPARISON OF PATIENT REACTIONS AND DIAGNOSTIC QUALITY FOR HYSTEROSALPINGOGRAPHY USING IONIC AND NONIONIC CONTRAST-MEDIA, Academic radiology, 2(2), 1995, pp. 123-127
Rationale and Objectives. We compared adverse reactions and image qual
ity for hysterosalpingography (HSG) performed with ionic (diatrizoate
meglumine combined with iodipamide meglumine [DM+IM]) and nonionic (io
hexol) contrast media. Methods. We performed a study of 95 patients wh
o had HSG and were randomly selected to receive DM+IM or iohexol. Pati
ents reported episodes of abdominal pain and other adverse reactions i
mmediately and 24 hr after the procedure and categorized severity of s
ymptoms on a subjective scale. Two radiologists evaluated image qualit
y for diagnosis. Results. Prevalence of abdominal pain and other react
ions both immediately and 24 hr after HSG was lower in patients who re
ceived iohexol than in patients who received DM+IM. Moderate or severe
abdominal pain was significantly lower in the iohexol group than in t
he DM+IM group (p<.05). Visualization of the uterine cavity and ampull
ary rugae was judged excellent with both contrast media (87% with iohe
xol and 92% with DM+IM). Conclusion. Iohexol and DM+IM are excellent c
ontrast media for use during HSG; iohexol 300 may cause fewer episodes
of more severe and prolonged abdominal pain.