SPECTRAL-ANALYSIS AND STRUCTURAL IDENTIFICATION OF A MAJOR DEFLAZACORT METABOLITE IN MAN

1. The structure of a previously reported but uncharacterized major me tabolite of deflazacort in man, designated V, has been characterized b y nmr, MS and IR spectral techniques. 2. The major changes in V relati ve to deflazacort are deacetylation to form the 21-alcohol and A-ring modification to the 1,2-epoxy-3-hydrox-4 analogue. 3. Based on the spe ctral data and comparison with model compounds the structure, includin g relative stereochemistry, is (1 beta, 2 beta, 3 beta, 11 beta, 16 -e poxy-3,11,21-trihydroxy-2'-methyl-5H'-pregn-4-4- eno[17,16-d]oxazol-20 -one.