PAECILOQUINONE-A, PAECILOQUINONE-B, PAECILOQUINONE-C, PAECILOQUINONE-D, PAECILOQUINONE-E AND PAECILOQUINONE-F - NEW POTENT INHIBITORS OF PROTEIN-TYROSINE KINASE PRODUCED BY PAECILOMYCES-CARNEUS .2. CHARACTERIZATION AND STRUCTURE DETERMINATION

Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paec ilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly H-1 NMR and C-13 NMR. The substitution pattern was established by investigation of the respectiv e methylated derivatives.