EFFECTS ON BLOOD-PRESSURE OF CAFFEIC ACID ANALOGS ISOLATED FROM SALVIAE MILTIORRHIZAE RADIX IN RATS WITH ADENINE-INDUCED RENAL-HYPERTENSION

The effects of caffeic acid analogues isolated from Salviae Miltiorrhi zae Radix were examined in rats with adenine-induced renal failure and hypertension, Systolic, mean and diastolic blood pressures were decre ased after magnesium lithospermate B administration. Oral administrati on of lithospermic acid B also decreased these blood pressure values e ven though the effects were weaker than those of magnesium lithosperma te B, However, rats given lithospermic acid, rosmarinic acid or caffei c acid showed no appreciable changes in systolic, mean or diastolic bl ood pressure throughout the experimental period. Urinary excretion of both kallikrein and sodium was increased significantly in rats given m agnesium lithospermate B or lithospermic acid B, These results indicat e that the action of these compounds shows a structure-specific patter n.