Staphylococcus aureus has a long association with nosocomial infection
. Problems date from the 1950s, although methicillin-resistant Staphyl
ococcus aureus (MRSA) did not emerge until the following decade. Initi
ally the pathogenicity of antibiotic-resistant strains was underestima
ted, and is still sometimes questioned, but today most authorities con
sider MRSA a serious threat, especially given current preoccupation wi
th cost-effectiveness within the health service: nosocomial infection
is associated with increased expenditure and may be regarded as a hall
mark of indifferent nursing and medical care. This review documents th
e emergence of MRSA and recognition of the ensuing problems throughout
the 1980s and early 1990s, with suggestions for nursing activities wh
ich could contribute towards improved control. Lessons learnt during o
utbreaks are seen to be of value, but there is also a need for staff a
t ward level to review routine practice continually so that awareness
of activities likely to result in cross-infection is maintained. The u
se of protective clothing emerges as less important than handwashing,
which may be periodically audited to maintain standards.