A STUDY OF AMBREIN TREATMENT FOR THE EVALUATION OF CHANGE IN PLASMA BIOCHEMICAL PARAMETERS IN RATS

Biochemical effects of acute and subacute treatments with ambrein were investigated in rats by measuring the total proteins, cholesterol, tr iglycerides, GOT, GPT and alkaline phosphatase in the blood plasma. Al so, determinations of prothrombin time (PT), partial thrombin time (PT T), thrombin time (TT) and fibrinogen level were performed. Furthermor e, changes in plasma electrolyte concentration were studied. Ambrein a dministered i.p. did not cause any toxic symptoms in the liver as reve aled by the histology of the liver tissue both in acute and subacute t reatments. Ambrein itself did not significantly affect the plasma prot ein, cholesterol, GOT and GPT profiles, but lowered alkaline phosphata se at high doses (50 and 250 mg/kg) after subacute treatment. Thus far , no specific pattern of action of ambrein in electrolyte control has been found. However, it increased PT, PTT and TT and decreased fibrino gen levels in both the acute and subacute studies, pointing towards it s potential as an anticoagulant and antifibrinogenic agent.