PEPTIDE MODIFICATION BY INTRODUCTION OF ALPHA-TRIFLUOROMETHYL SUBSTITUTED AMINO-ACIDS

Authors
SEWALD N HOLLWECK W MUTZE K SCHIERLINGER C SEYMOUR LC GAA K BURGER K KOKSCH B JAKUBKE HD
Citation
N. Sewald et al., PEPTIDE MODIFICATION BY INTRODUCTION OF ALPHA-TRIFLUOROMETHYL SUBSTITUTED AMINO-ACIDS, Amino acids, 8(2), 1995, pp. 187-194
Citations number
15
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
8
Issue
2
Year of publication
1995
Pages
187 - 194
Database
ISI
SICI code
0939-4451(1995)8:2<187:PMBIOA>2.0.ZU;2-G
Abstract
Methodology for the synthesis and incorporation of alpha-trifluorometh yl substituted amino acids into N- and C-terminal position of peptides is described. The incorporation of alpha-trifluoromethyl substituted amino acids into strategical positions of peptides enhances proteolyti c stability and lipophilicity. Furthermore, it improves transport rate s in vivo and permeability through certain body barriers.