APPLICATION OF HEXAFLUOROACETONE AS PROTECTING AND ACTIVATING REAGENTIN AMINO-ACID AND PEPTIDE CHEMISTRY

Using hexafluoroacetone as protecting and activating reagent, multifun ctional amino acids like aspartic acid can be functionalized regiosele ctively. This strategy offers i.a. a two-step synthesis for aspartame and preparatively simple access to multifunctional natural and unnatur al amino acids, like 4-oxo-L-amino acids, 5-diazo-4-oxo-L-amino acids, 4-substituted L-proline derivatives and various heterocyclic L-amino acids. On application of this strategy to amino diacetic acid N-substi tuted glycines become readily available.