LAMOTRIGINE

Lamotrigine is a novel antiepileptic that, although its mechanism is n ot completely understood, appears to affect voltage-activated sodium c hannels, resulting in inhibition of the presynaptic release of the exc itatory neurotransmitter glutamate. It is well absorbed after oral adm inistration, Its route of elimination is hepatic glucuronidation, whic h is susceptible to both hepatic microsomal enzyme-inducing and -inhib iting agents. In clinical trials lamotrigine was effective as add-on t herapy for refractory partial seizures in adults, Small, trials sugges t the feasibility of monotherapy, but further controlled trials are wa rranted to support this practice. Additional data indicate the utility of lamotrigine for generalized seizures. Reported side effects are ra sh, nausea, vomiting, blurred vision, diplopia, and vision abnormaliti es. Lamotrigine appears to be an attractive alternative to currently a vailable antiepileptics.