EFFECTS OF ANF PROHORMONE PEPTIDES IN CONSCIOUS PRIMATES

1. Recent studies suggest that amino-terminal peptides from the atrial natriuretic factor (ANP) prohormone are natriuretic. 2. The effects o f pro ANF 31-67 and ANF 99-126 on renal function were studied in consc ious non-human primates (Macaca fascicularis). 3. Results show that pr o ANF 31-67 and ANF 99-126 are diuretic and natriuretic and that when the two peptides are given in combination sodium excretion increases i n an additive fashion. 4. These results indicate that multiple peptide s from the ANF prohormone are natriuretic. Furthermore, these findings suggest that the combined action of these peptides causes the natriur esis that occurs after the release of endogenous atrial peptides.