EFFECTS OF CHLORPYRIFOS ON NEURONAL DEVELOPMENT IN RAT EMBRYO MIDBRAIN MICROMASS CULTURES

Authors
COSENZA ME BIDANSET J
Citation
Me. Cosenza et J. Bidanset, EFFECTS OF CHLORPYRIFOS ON NEURONAL DEVELOPMENT IN RAT EMBRYO MIDBRAIN MICROMASS CULTURES, Veterinary and human toxicology, 37(2), 1995, pp. 118-121
Citations number
16
Categorie Soggetti
Toxicology,"Veterinary Sciences
Journal title
Veterinary and human toxicology → ACNP
ISSN journal
01456296
Volume
37
Issue
2
Year of publication
1995
Pages
118 - 121
Database
ISI
SICI code
0145-6296(1995)37:2<118:EOCOND>2.0.ZU;2-9
Abstract
Chorpyrifos (CPF) Is a broad-spectrum organophosphate insecticide used to control mosquitos and household insects. In man it has toxic effec ts on the central nervous system, the cardiovascular system and the re spiratory system. This study investigated the toxicity of CPF on nervo us system development using the midbrain micromass culture system. Chl orpyrifos was tested as a marketed formulation and in 3 solvents. All demonstrated toxicity in midbrain micromass cells with IC50 values bel ow 30 ug/mL, indicating a potent teratogen.