PROMOTION OF EXPERIMENTAL LIVER METASTASIS BY TUMOR-NECROSIS-FACTOR

Citation
P. Orosz et al., PROMOTION OF EXPERIMENTAL LIVER METASTASIS BY TUMOR-NECROSIS-FACTOR, International journal of cancer, 60(6), 1995, pp. 867-871
Citations number
26
Categorie Soggetti
Oncology
ISSN journal
00207136
Volume
60
Issue
6
Year of publication
1995
Pages
867 - 871
Database
ISI
SICI code
0020-7136(1995)60:6<867:POELMB>2.0.ZU;2-L
Abstract
Models for experimental metastasis were established to investigate the influence of rmTNF on tumor-colony formation in the liver. Highly met astatic: lymphoma tumor cells were either injected i.v. or inoculated s.c. to form spontaneous metastases. In both systems, administration o f rmTNF to the animals led to significant enhancement of the number of liver metastases in comparison with control groups. The number of met astatic tumor-cell colonies at an early stage of metastasis was increa sed, as well as the number of surface metastases in a late stage. Cons equently; TNF-treated animals revealed a higher mortality. The optimal time for TNF to exert this metastasis-enhancing effect was found to b e 7 days after tumor inoculation. In vitro adhesion of the lymphoma tu mor cells to a mouse endothelioma cell line was strongly inhibited by monoclonal antibodies interfering with the interaction of VCAM-1 with VLA-4. These results support and extend earlier results with a fibrosa rcoma lung colonization model. In addition, they show that stimulation of the immune system in tumor-bearing hosts activates tumor-promoting pathways, in addition to having possible beneficial effects. (C) 1995 Wiley-Liss, Inc.