INFLUENCE OF 2 SALICYLATE COMPONENTS ON THE PARTICLE-SIZE OF AN OIL-IN-WATER EMULSION WITH NONIONIC SURFACTANTS

Citation
G. Mestres et al., INFLUENCE OF 2 SALICYLATE COMPONENTS ON THE PARTICLE-SIZE OF AN OIL-IN-WATER EMULSION WITH NONIONIC SURFACTANTS, Drug development and industrial pharmacy, 22(12), 1996, pp. 1193-1199
Citations number
20
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
ISSN journal
03639045
Volume
22
Issue
12
Year of publication
1996
Pages
1193 - 1199
Database
ISI
SICI code
0363-9045(1996)22:12<1193:IO2SCO>2.0.ZU;2-1
Abstract
This paper reports a study undertaken using techniques of static and d ynamic light scattering to investigate the influence of sodium salicyl ate and methyl salicylate on droplet size of oil-in-water emulsions. T he rates of changes were measured by determining the size and distribu tion of the oil droplet in the material. All emulsions showed a bimoda l size distribution; the mean diameters and polydispersity were calcul ated from intensity. These data were analyzed with nonlinear regressio ns and bootstrap methodology. An amount of methyl salicylate component induced a decrease of mean diameter and standard deviation. On the co ntrary, sodium salicylate entailed the growth of all droplet populatio ns and coalescence for the highest concentration.