G. Mestres et al., INFLUENCE OF 2 SALICYLATE COMPONENTS ON THE PARTICLE-SIZE OF AN OIL-IN-WATER EMULSION WITH NONIONIC SURFACTANTS, Drug development and industrial pharmacy, 22(12), 1996, pp. 1193-1199
This paper reports a study undertaken using techniques of static and d
ynamic light scattering to investigate the influence of sodium salicyl
ate and methyl salicylate on droplet size of oil-in-water emulsions. T
he rates of changes were measured by determining the size and distribu
tion of the oil droplet in the material. All emulsions showed a bimoda
l size distribution; the mean diameters and polydispersity were calcul
ated from intensity. These data were analyzed with nonlinear regressio
ns and bootstrap methodology. An amount of methyl salicylate component
induced a decrease of mean diameter and standard deviation. On the co
ntrary, sodium salicylate entailed the growth of all droplet populatio
ns and coalescence for the highest concentration.