M. Becireviclacan et al., DISSOLUTION CHARACTERISTICS OF NIFEDIPINE COMPLEXES WITH BETA-CYCLODEXTRINS, Drug development and industrial pharmacy, 22(12), 1996, pp. 1231-1236
Formation of nifedipine complexes with beta-cyclodextrin, hydroxypropy
l-beta-cyclodextrin, and DIMEB in solution was studied by the phase so
lubility method. Solid complexes of nifedipine were prepared by partia
l and complete solubilization of nifedipine using the freeze- and spra
y-drying techniques. The complexation led to an improvement in the dis
solution rate of the drug. The relative potency of beta-cyclodextrins
to enhance the dissolution rate of nifedipine was in order: beta-cyclo
dextrin < hydroxypropyl-beta-cyclodextrin < DIMEB, which clearly fits
the magnitude of stability constant data of the complexes. The dissolu
tion rates of the free drug, complexes, and physical mixture of drug a
nd cyclodextrins from constant surface area disks were also investigat
ed.