LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY WITH COLLISION-INDUCED DISSOCIATION OF ARACHIDONIC-ACID METABOLITES DERIVATIZED WITH AMINOBENZENESULPHONIC ACID

Authors
YANG Y GRIFFITHS WJ LINDGREN JA SJOVALL J
Citation
Y. Yang et al., LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY WITH COLLISION-INDUCED DISSOCIATION OF ARACHIDONIC-ACID METABOLITES DERIVATIZED WITH AMINOBENZENESULPHONIC ACID, Rapid communications in mass spectrometry, 9(4), 1995, pp. 289-299
Citations number
33
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
9
Issue
4
Year of publication
1995
Pages
289 - 299
Database
ISI
SICI code
0951-4198(1995)9:4<289:LMWCD>2.0.ZU;2-J
Abstract
A fused-silica capillary high-performance liquid chromatography column (i.d. 0.25 mm) packed with octadecylsilane-bonded silica has been use d on-line with continuous-flow negative-ion fast-atom bombardment (FAB ) mass spectrometry for the separation and structural analysis of seri es of fatty acids and arachidonic acid metabolites derivatized with 4- aminobenzenesulphonic acid. Negative-ion FAB spectra of the derivatize d lipids showed strong [M - H](-) pseudomolecular ions. Collision-indu ced dissociation of these anions produced structurally informative dau ghter ions, arising from charge-remote fragmentations.