A case of focal acantholytic dyskeratosis (FAD) in a 55-year-old woman
is reported. The lesion was located on the lip and manifested as a pa
inful, oozing, crusted patch lasting for 20 years. Although FAD has be
en recently reported in the mucosa of the anal canal without cutaneous
lesion, we report a case of FAD that appeared on the lip with clinica
l manifestation.