INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES CONTAINING EXTENDED ALKYL RESIDUES AT P-1

Authors
ESSER CK KOPKA IE DURETTE PL HARRISON RK NIEDZWIECKI LM IZQUIERDOMARTIN M STEIN RL HAGMANN WK
Citation
Ck. Esser et al., INHIBITION OF MATRIX METALLOPROTEINASES BY N-CARBOXYALKYL PEPTIDES CONTAINING EXTENDED ALKYL RESIDUES AT P-1, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 539-542
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
539 - 542
Database
ISI
SICI code
0960-894X(1995)5:6<539:IOMMBN>2.0.ZU;2-A
Abstract
A series of N-carboxyalkyl peptides were prepared to test their inhibi tory activity against human stromelysin (MMP-3), collagenase (MMP-1), and gelatinase A (MMP-2). Linear alkyl and omega-aminoalkyl residues w ere employed as replacements for a phenethyl group yielding inhibitors with in vitro activities comparable to their corresponding aromatic a nalogs.