4-(2-PYRIDYL)-5-PHENYLTHIAZOLES AS NOVEL NON-BICYCLIC REVERSIBLE INHIBITORS OF THE GASTRIC H+ K+-ATPASE/

Authors
IFE RJ LEACH CA POPE AJ THEOBALD CJ
Citation
Rj. Ife et al., 4-(2-PYRIDYL)-5-PHENYLTHIAZOLES AS NOVEL NON-BICYCLIC REVERSIBLE INHIBITORS OF THE GASTRIC H+ K+-ATPASE/, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 543-546
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
543 - 546
Database
ISI
SICI code
0960-894X(1995)5:6<543:4ANNRI>2.0.ZU;2-R
Abstract
4-(2-Pyridyl)-5-phenylthiazoles, 3 (X = S), are shown to be reversible , K+-competitive gastric H+/K+-ATPase inhibitors. It is suggested that a hydrogen-bond between the protonated pyridine and the thiazole may help the molecule adopt a conformation which mimics that of the previo usly described quinoline based inhibitors such as 1 and 2.