SYNTHESIS OF YLOXY)METHYL-4-DEMETHOXY-6,7-DIDEOXY-DAUNOMYCINON, A NEWDNA INTERCALATOR RELATED TO ANTHRACYCLINES

Authors
DIENES Z VOGEL P
Citation
Z. Dienes et P. Vogel, SYNTHESIS OF YLOXY)METHYL-4-DEMETHOXY-6,7-DIDEOXY-DAUNOMYCINON, A NEWDNA INTERCALATOR RELATED TO ANTHRACYCLINES, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 547-550
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
547 - 550
Database
ISI
SICI code
0960-894X(1995)5:6<547:SOYAN>2.0.ZU;2-F
Abstract
The hydrochloride of (-)-(8R)-8-acetyl-7,8,9,10-tetrahydro-6, ydroxy-1 1-[3'-aminopropyloxy)methyl]naphthacene-5, 12-dione was derived from t hyl)-2,3,5,6-tetramethylidene-7-oxabicyclo[2.2.2] heptane and shown to be a moderate intercalator of calf thymus DNA type XV.