INFLUENCE OF THE ABSOLUTE-CONFIGURATION AT C-4 IN THE BINDING OF D-MYO INOSITOL 1,4,5-TRISPHOSPHATE ANALOGS TO IP3 RECEPTOR

Authors
POIROT E BOURDON H CHRETIEN F CHAPLEUR Y BERTHON B HILLY M MAUGER JP GUILLON G
Citation
E. Poirot et al., INFLUENCE OF THE ABSOLUTE-CONFIGURATION AT C-4 IN THE BINDING OF D-MYO INOSITOL 1,4,5-TRISPHOSPHATE ANALOGS TO IP3 RECEPTOR, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 569-572
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
569 - 572
Database
ISI
SICI code
0960-894X(1995)5:6<569:IOTAAC>2.0.ZU;2-R
Abstract
Biomimetic syntheses of enantiomerically pure 3-deoxy-D-muco- and D-my o-inositol-1,4,5 trisphosphate from D-glucose an:described. Preliminar y biological studies show a dramatic influence of the stereochemistry at C-4 on the binding to IP3 receptor.