STEREOSELECTIVE SYNTHESIS AND EVALUATION OF ALL STEREOISOMERS OF Z4349, A NOVEL AND SELECTIVE MU-OPIOID ANALGESIC

Authors
NAPOLETANO M DELLA BD FRAIRE C GRANCINI G MASOTTO C RICCIARDI S ZAMBON C
Citation
M. Napoletano et al., STEREOSELECTIVE SYNTHESIS AND EVALUATION OF ALL STEREOISOMERS OF Z4349, A NOVEL AND SELECTIVE MU-OPIOID ANALGESIC, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 589-592
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
589 - 592
Database
ISI
SICI code
0960-894X(1995)5:6<589:SSAEOA>2.0.ZU;2-Z
Abstract
A stereoselective synthesis of 1 was devised in order to obtain all 12 possible isomers. The pharmacological data clearly show a highly ster eochemical requirement for the affinity and selectivity towards the mu -receptor and the related analgesic activity.