WIEDENDIOL-A AND WIEDENDIOL-B, CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS FROM THE MARINE SPONGE XESTOSPONGLIA-WIEDENMAYERI

Authors
COVAL SJ CONOVER MA MIERZWA R KING A PUAR MS
Citation
Sj. Coval et al., WIEDENDIOL-A AND WIEDENDIOL-B, CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS FROM THE MARINE SPONGE XESTOSPONGLIA-WIEDENMAYERI, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 605-610
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
605 - 610
Database
ISI
SICI code
0960-894X(1995)5:6<605:WAWCET>2.0.ZU;2-C
Abstract
Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit c holesteryl ester transfer protein (CETP), have been isolated form the marine sponge Xestospongia wiedenmayeri. Additional related marine nat ural products were also evaluated for CETP inhibition. Compounds that inhibit the activity of CETP may find utility as antiatherosclerosis t herapy.