(+ -)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-METHYL-5-ARYL-2-PENTEN-4-YNYL) OXIMES - POTENT MUSCARINIC AGONISTS/

Authors
TECLE H LAUFFER DJ DAVIS RE MIRZADEGAN T MORELAND DW SCHWARZ RD THOMAS AJ RABY C EUBANKS D BRANN MR JAEN JC
Citation
H. Tecle et al., (+ -)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-METHYL-5-ARYL-2-PENTEN-4-YNYL) OXIMES - POTENT MUSCARINIC AGONISTS/, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 637-642
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
6
Year of publication
1995
Pages
637 - 642
Database
ISI
SICI code
0960-894X(1995)5:6<637:(-O>2.0.ZU;2-C
Abstract
Synthesis and SAR of a new class of 1-azabicyclo[2.2.1]heptan-3-one, O -(3-methyl-5-aryl-2-penten-4-ynyl) oxime muscarinic agonists are descr ibed. Depending on the geometry of the C=N and C=C bonds, subnanomolar potency and/or high efficacy are achieved.