Recent development in the non-parametric regression method suggests th
at the unknown optimal smoothing parameter derived from the conditiona
l mean squared prediction error is very hard to estimate. We attempt t
o provide some justification of this observation by showing that the p
rediction error itself is almost impassible to estimate. In particular
, the popular cross validation method fails to provide a reasonable es
timate in the sense that the correlation coefficient between the predi
ction error and its estimate is asymptotically negative and tends to z
ero. The problem, however, is not with the cross validation method bec
ause a similar result holds in the general regression setting regardle
ss of the type of estimate and whether smoothing is involved or not.