CYTOLYSIS DOES NOT PER SE INDUCE LIPID-PEROXIDATION - EVIDENCE IN MAN

An increasing bulk of data counters the opinion that cell death and ly sis necessarily trigger the formation and release of detectable amount s of molecules that are markers of lipid peroxidation. Plasma levels o f thiobarbituric-acid-reacting compounds, protein-aldehyde fluorescent adducts, lipid peroxides, and endogenous antioxidant compounds were m onitored versus controls, during intensive care treatment, in six pati ents seriously poisoned by ingestion of the mushroom Amanita Phalloide s. All six patients showed cytolysis, and four of them massive tissue necrosis, as monitored in terms of serum transaminases. In all six pat ients, however, the blood parameters of redox equilibrium measured wer e within the normal range for the whole observation period.