PENTYLENETETRAZOLE KINDLING IMPAIRS LONG-TERM-MEMORY IN RATS

Authors
GENKOVAPAPAZOVA MG LAZAROVABAKAROVA MB
Citation
Mg. Genkovapapazova et Mb. Lazarovabakarova, PENTYLENETETRAZOLE KINDLING IMPAIRS LONG-TERM-MEMORY IN RATS, European neuropsychopharmacology, 5(1), 1995, pp. 53-56
Citations number
15
Categorie Soggetti
Neurosciences,"Pharmacology & Pharmacy
Journal title
European neuropsychopharmacology → ACNP
ISSN journal
0924977X
Volume
5
Issue
1
Year of publication
1995
Pages
53 - 56
Database
ISI
SICI code
0924-977X(1995)5:1<53:PKILIR>2.0.ZU;2-N
Abstract
The effect of pentylenetetrazole (PTZ) kindling on learning and retent ion in active (shuttle-box) and passive (step-down) avoidance was stud ied in rats. PTZ kindling did not impair learning and significantly di sturbed long-term memory estimated from retention tests, i.e. PTZ kind ling induced a retrograde amnesia in the active and passive avoidance situations. The present results support the view that memory deficit i s an integral part of epilepsy.