GUILLAIN-BARRE-SYNDROME FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION

The pathogenesis of the Guillain-Barre syndrome (GBS) is felt to invol ve alterations in cellular and humoral immune responses. We report the case of a 44-year-old female with stage IV breast cancer who develope d GBS 2 days after receiving high dose chemotherapy with bone marrow a nd peripheral progenitor cell support, and granulocyte-macrophage colo ny stimulating factor (GM-CSF). Her clinical status stabilized with pl asmapheresis. This report lends further support to hypotheses regardin g cellular immune alterations in the pathogenesis of GBS.