PRODUCT DEVELOPMENT STUDIES ON SUSPENSION DOSAGE FORM .1. EFFECT OF TEMPERATURE ON SUSPENSION ACTIVITY OF PSEUDOPLASTIC POLYMERS

To assess the suspension activity of some pseudoplastic polymers, CMC- high and low viscous, Sodium alginate and guar gum three model drugs F urazolidone, Rifampicin and Cotrimoxazole (mixture of Trimethopim and Sulphamethoxazole) were suspended in the mucilages of these polymers a nd the suspensions were stored at four temperatures 10-degrees, 20-deg rees, 30-degrees and 40-degrees-C over a period of six months. The rel ationship between apparent viscosity of the suspending agent and sedim entation ratio and also how the storage temperature effects on sedimen tation had been observed.