FLUORESCENT IN-SITU HYBRIDIZATION (FISH) AS AN AID TO MARKER CHROMOSOME IDENTIFICATION IN PRENATAL-DIAGNOSIS

Authors
AMIEL A FEJGIN M APPELMAN Z SHAPIRO I GABER E BACHAR A ZAMIR R KEDAR I GOLBUS M
Citation
A. Amiel et al., FLUORESCENT IN-SITU HYBRIDIZATION (FISH) AS AN AID TO MARKER CHROMOSOME IDENTIFICATION IN PRENATAL-DIAGNOSIS, European journal of obstetrics, gynecology, and reproductive biology, 59(1), 1995, pp. 103-107
Citations number
22
Categorie Soggetti
Reproductive Biology","Obsetric & Gynecology
Journal title
European journal of obstetrics, gynecology, and reproductive biology → ACNP
ISSN journal
03012115
Volume
59
Issue
1
Year of publication
1995
Pages
103 - 107
Database
ISI
SICI code
0301-2115(1995)59:1<103:FIH(AA>2.0.ZU;2-J
Abstract
Five cases of supernumerary marker chromosomes were identified in pren atal diagnosis as derived from chromosomes 18, X, and Y. One unexpecte d finding was in a case where the PCR was positive for the SRY gene wh ile fluorescence in situ hybridization was positive for two X centrome res. In another case with an X derived supernumerary marker the newbor n was phenotypically normal. Two women with fetal mar(18) and mar(Xp) decided to terminate the pregnancy. The fifth pregnancy had a karyotyp e of 46,XX,-15,+der(15)t(Y:15)(q11,23;p13). A phenotypically normal gi rl was born at term.