HETEROBIFUNCTIONAL POLY(ETHYLENE OXIDE) - SYNTHESIS OF ALPHA-METHOXY-OMEGA-AMINO AND ALPHA-HYDROXY-OMEGA-AMINO PEOS WITH THE SAME MOLECULAR-WEIGHTS

Well-defined alpha-methoxy-omega-amino and alpha-hydroxy-omega-amino p oly(ethylene oxide)s (PEOs) were obtained after chemical modifications of alpha-hydroxy-omega-allyl PEG which was synthesized by anionic pol ymerization of ethylene oxide (EO) with allyl alcoholate as initiator; molecular weights of the prepolymer were controlled by the monomer/in itiator ratio. Addition of methyl iodide on the hydroxy function of th is prepolymer led to an alpha-methoxy-omega-allyl PEG; completion of t he reaction and purity of the resulting polymer were demonstrated by H -1, C-13 NMR and GPC studies. Addition reactions of 2-amino-ethanethio l hydrochloride on alpha-hydroxy-omega-allyl PEO and alpha-methoxy-ome ga-allyl PEO in the presence of azobisisobutyronitrile (AIBN) led to t he expected homopolymers without any side reactions as shown by H-1 an d C-13 NMR spectra.