SERUM ALDOLASE LEVEL IS A USEFUL INDICATOR OF DISEASE-ACTIVITY IN EOSINOPHILIC FASCIITIS

The serum levels of muscle enzymes have been considered normal in pati ents with eosinophilic fasciitis (EF). We observed elevated serum aldo lase levels in 3 patients with EF. Serum creatinine kinase levels were within the normal range. We measured the aldolase levels longitudinal ly. In all patients, the levels decreased to the normal range after or al corticosteroid treatment, and skin sclerosis improved. Afterwards, serum aldolase levels increased again, with the recurrence of skin scl erosis. These observations suggest that serum aldolase level may be a useful indicator of disease activity.