PULMONARY NOCARDIOSIS IN A PATIENT WITH A BONE-MARROW TRANSPLANT

Infection with nocardia is rare in BMT patients, We describe the first reported case of pulmonary nocardiosis in an allogeneic marrow recipi ent with graft-versus-host disease, The patient developed nocardial in fection while receiving trimethoprim-sulfamethoxazole as prophylaxis a gainst Pneumocystis, The salient clinical presentation was right lower lung consolidation; the diagnosis was established by prolonged incuba tion of an open lung biopsy specimen. Antibiotic therapy included time ntin and later, imipenem. However, the patient died with uncontrolled infection, Necropsy revealed nocardial lung abscesses and disseminated infection from cytomegalovirus.