ACUTE AND CHRONIC EFFECT OF MOLSIDOMINE EXTENDED-RELEASE ON EXERCISE CAPACITY IN PATIENTS WITH STABLE ANGINA, A DOUBLE-BLIND CROSS-OVER CLINICAL-TRIAL VERSUS PLACEBO

A double-blind, placebo-controlled, crossover study was performed in 5 0 patients with ischemic heart disease and stable angina to determine the duration of efficacy of 8 mg molsidomine in extended-release form, Exercise testing was performed at baseline and 2, 4, 6, 8, and 10 h a fter intake of either the medication or the placebo. Total duration of exercise (in minutes) and total work performance (workload X min) was significantly improved in the molsidomine retard group, not only comp ared with baseline but also with placebo for all time-points. ST segme nt depression at 60 W and at maximal exercise improved similarly until 10 h after molsidomine retard treatment. The rate-pressure product (h eart rate X systolic blood pressure) showed significant improvement on ly at 60 W., No attenuation of the obtained effects was observed after 14 days of treatment. The number of anginal attacks and the consumpti on of sublingual nitroderivates were significantly reduced with molsid omine retard 8 mg as compared with placebo. Molsidomine retard 8 mg is effective until at least 10 h after oral (p.o.) intake. A dose schedu le of molsidomine retard 8 mg twice daily definitely reduces anginal s ymptoms.