Pj. Bijlstra et al., EFFECT OF LONG-TERM ANGIOTENSIN-CONVERTING ENZYME-INHIBITION ON ENDOTHELIAL FUNCTION IN PATIENTS WITH THE INSULIN-RESISTANCE SYNDROME, Journal of cardiovascular pharmacology, 25(4), 1995, pp. 658-664
Cardiovascular risk factors such as hypertension, diabetes, and dyslip
emia are associated with an impaired endothelium-dependent vasodilatio
n. In patients with type 2 diabetes mellitus, these risk factors are f
requently clustered. We investigated whether long-term treatment with
the angiotensin-converting enzyme (ACE) inhibitor perindopril can impr
ove endothelium-dependent vasodilation in this particular group of pat
ients. We selected 10 patients with type 2 diabetes and hypertension (
age 59.4 +/- 3.2 years, body mass-index 29.7 +/- 1.5 kg . m(-2), blood
pressure 169 +/- 6/92 +/- 1 mm Hg, total cholesterol 6.6 +/- 0.3 mM),
Using venous occlusion plethysmography, we recorded the increases in
forearm blood flow (FBF) in response to three vasodilator stimuli: (a)
5 min of forearm ischemia, (b) infusion of the endothelium-dependent
vasodilator methacholine (Mch) into the brachial artery (0.03, 0.3, an
d 1.0 mu g/min/100 ml), and (c) intraarterial infusion of the endothel
ium-independent vasodilator sodium nitroprusside (SNP 0.06, 0.2, 0.6 m
u g/min/100 ml). This procedure was repeated after 6 months of treatme
nt with perindopril 4-8 mg/day. Forearm vascular resistance (FVR) was
calculated by the quotient of the mean arterial pressure (MAP) and the
FBF. Perindopril reduced blood pressure (BP) by 19/10 mm Hg (p < 0.05
) and increased baseline FVR, but improved neither the maximal percent
age decrease in vascular resistance induced by Mch (from -80 +/- 2 to
-82 +/- 2%) nor that induced by SNP (from -73 +/- 3 to -72 +/- 3%). Pe
rindopril decreased the FVR reached after the ischemic stimulus from 6
.5 +/- 1.2 to 4.8 +/- 0.6 U (p < 0.05). Six months of treatment with p
erindopril improved neither the endothelium-dependent nor endo thelium
-independent vasodilation, but significantly reduced minimal FVR (p <
0.05). These observations suggest a reduction of structural vascular c
hanges after long-term ACE inhibition.