COLOR-CODED-DUPLEX SONOGRAPHY AFTER INTRA URETHRAL APPLICATION OF PROSTAGLANDIN-E1 ERECTILE DYSFUNCTION

When the pathomechanism of erectile dysfunction is obscure, intraureth ral administration of prostaglandin E1 is followed by a marked increas e in blood flow velocity in the penile arteries as measured by color-c oded Duplex sonography. This increase compares to that following intra cavernous administration of half the dose of prostaglandin E1. The dif ference in the effects after intraurethral and intracavernous administ ration is the missing rigidity after intraurethral application; there must be a loss of pharmacological efficacy to the smooth penile muscle s. Clinical efficacy is to be expected with higher intraurethral dosag e.