BACKGROUND. Some infections do not respond readily to antibiotic thera
py. In particular, fungi and mycobacteria often require prolonged trea
tment, which is expensive and prone to adverse effects. OBJECTIVE. TO
investigate the role of surgery in the treatment of skin infections. M
ETHODS. Literature review. RESULTS. Infections caused by atypical myco
bacteria, certain fungi, and those involving joints often respond well
to surgical treatments. In several situations excision produces a hig
her cure rate than antibiotic treatment. CONCLUSION. Excision, drainag
e, or debridement has been shown to be superior to drug therapy in sev
eral infections and a reasonable alternative in others.