A variety of diffuse and focal disease processes affect the liver. MRI
is likely the imaging modality of choice for investigation of patient
s suspected of having diffuse disease such as cirrhosis, hemochromatos
is, or fatty infiltration. MRI is extremely effective at detecting and
characterizing focal hepatic lesions. In particular, patients suspect
ed of possessing hemangiomas, hepatocellular carcinoma, or hypervascul
ar liver metastases are better evaluated by MRI than other imaging mod
alities. Immediate post gadolinium spoiled gradient echo and T2-weight
ed fat suppressed spin echo are very effective at lesion detection, wh
ereas serial post gadolinium spoiled gradient echo is essential for le
sion characterization. New fast T2-weighted sequences and tissue speci
fic contrast agents may further increase the role of liver MRI by shor
tening exam time and increasing sensitivity and specificity, respectiv
ely.